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KMID : 0369819900200040217
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Jorunal of Korean Pharmaceutical Sciences
1990 Volume.20 No. 4 p.217 ~ p.222
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Synthesis of pt (Ⅱ ) Complexes Containing Diphosphines and Evaluation of Antitumor Activity
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노영수/Noh YS
노지 마사히데/Noji Masahide
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Abstract
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New antitumor-active pt(II) complexes of trans-l-diamine cyclohexane containing diphosphines as a leaving group were synthesized. The structures of the pt(II) complexes were determined by analyzing the infrared and 31P?nuclear magnetic resonance spectra. Antitumor activities of the pt(II) complexes were tested against murine leukemia Ll210 according to the protocol of the National Cancer Institute. All the pt(II) complexes Synthesized were antitumor-active. In particular, water-soluble [pt(trans?l?dach)(DPPP)](NO3)2 exhibited excellent antitumor activity, giving T/C % values of 341 and 356 respectively, each with four cured mice out of six at a dose of 25 mg/kg. These pt(II) complexes are considered to be worthy of further development.
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KEYWORD
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